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KMID : 0869620190360040455
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Journal of Korean Society of Hospital Pharmacists
2019 Volume.36 No. 4 p.455 ~ p.461
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Correlation Analysis between Nebulized-Salbutamol Dose and Heart Rate in Critically Ill Pediatric Patients
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Ko Eun-Bi
Kim Soo-Jung
Bae Hye-Jung
Jo Yun-Hee
Cho Yoon-Sook
Choi-Yu-Hyun
Park June-Dong
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Abstract
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Background : Nebulized-salbutamol is often used for patients hospitalized in the pediatric intensive care unit (PICU) in need of respiratory support. However, there is a lack of references to establish a guideline for dosage adjustment according to each age group. Thus, the purpose of this study was to analyze the correlation between the dose of nebulized-salbutamol and heart rate (HR) in critically ill pediatric patients.
Methods : This study included critically ill pediatric patients younger than age 18, who stayed in the PICU at Seoul National University Children’s Hospital July 1, 2015 July 31, 2018. The correlation between the change of HR and the dose of nebulized-salbutamol was analyzed. After that, there was an effort to identify further risk factors which can contribute to increasing HR during PICU hospitalization.
Results : There was a total of 340 cases of 87 patients who were administered nebulized-salbutamol within the first 24 hours of PICU hospitalization. There was no statistical difference in HR changes between the high dosage group (≥0.2 mg/kg/dose) and the low dosage group ( 0.2 mg/kg/dose) for the first 24 hours of administration (p=0.058). The subgroup analysis was conducted using 268 cases excluding 72 cases where body temperature change was observed. There was significant increase of HR in the high dosage group (p=0.017). Twenty-five of 87 patients showed a more rapid HR after the administration of nebulized-salbutamol during PICU hospitalization. Among patients younger than age 36 months, there was a statistically significant correlation between HR rise (OR=8.739; 95% CI, 2.146-35.590; p=0.002) and the high dosage of nebulized-salbutamol (OR=4.204; 95% CI, 1.384-12.776; p=0.011).
Conclusions : The use of high dosage nebulized-salbutamol in critically ill pediatric patients may have the potential to increase HR. Thus, close monitoring is recommended when it is administered to young patients with high dosage.
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KEYWORD
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Salbutamol, Pediatric intensive care units, Tachycardia
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